IFN-g Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b
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منابع مشابه
IFN-γ primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b.
The classical activation of macrophages, one of major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). The priming effect of IFN-γ can promote macrophages to secrete higher level of proinflammatory cytokines but lower level of the anti-inflammatory cytokines, enhancing microbicidal and tumoricidal activity of macrophages. However, the underly...
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